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International Maternal Pediatric Adolescent AIDS Clinical Trials Group

Primary Therapy
Prevention of Mother-to-Child Transmission
Complications of HIV
Vaccine/Immune-Based Therapy
International Resource Committee
IMPAACT Community Advisory Board
Resource Committees

Primary Therapy Scientific Committee

  • Introduction PowerPoint
  • What to start with - Strategy Concepts PowerPoint
  • Lopinavir exposure, efficacy, safety and toxicity in children receiving the new lower-strength tablet of Kaletra® (lopinavir/ritonavir 100/25 mg) dosed according to the WHO weight band dosing guidelines PowerPoint
  • Capsule: Open-Label, Multicenter, Phase I/II Dose Confirmation and Safety: MVC In Combination with OBT PowerPoint
  • Protocol Development PowerPoint
Prevention of Mother-to-Child Transmission Scientific Committee
  • PACTG 394 and PACTG/IMPAACT 1064: Role of Tenofovir in PMTCT - Pat Flynn, M.D. PowerPoint
  • AACTG 5190/PACTG 1054: Assessment of Safety and Toxicity Among Infants Born to HIV-1 Infected Women Enrolled in Antiretroviral Treatment Protocols in Diverse Areas of the World - Karin Nielsen, M.D., M.P.H. PowerPoint
  • NICHD HPTN 040/PACTG 1043: Phase III Randomized Trial of the Safety and Efficacy of Three Neonatal Antiretroviral Regimens for the Prevention of Intrapartum HIV-1 Transmission - Karin Nielsen, M.D., M.P.H. PowerPoint
  • HPTN 057: A Phase I Open Label Trial of the Safety and Pharmacokinetics of Tenofovir Disoproxil Fumarate (TDF) in HIV-1 Infected Pregnant Women and their Infants PowerPoint
  • Master Trial PowerPoint
  • Mother To Child HIV Transmission: Research Study Update - Lynne M. Mofenson, M.D. PowerPoint
  • IMPAACT P1025: Perinatal Core Protocol PowerPoint
  • PACTG/IMPAACT P1026S: Pharmacokinetic Properties Of Antiretroviral Drugs During Pregnancy PowerPoint
  • A randomized trial of single-dose tenofovir and emtricitabine to reduce viral resistance to non-nucleoside reverse transcriptase inhibitors in women receiving intrapartum nevirapine for perinatal HIV prevention PowerPoint
Complications of HIV Scientific Committee
  • IMPAACT P1063- a history PowerPoint
  • Pharmacology of Artemisinin-based Antimalarial Therapy (ACT) within the Context of Antiretroviral Therapy: Capsule 222 PowerPoint
  • Long-term Follow-up Issues PowerPoint
  • CS 4072: Phase I/II Trial of Oral Alendronate for HIV Infected Youth with Low Bone Mineral Density (BMD) - George K. Siberry, MD, MPH, Bret J. Rudy, MD PowerPoint
  • Getting from 6 to 3, and including children in the process - Bill Burman PowerPoint
Vaccine/Immune-Based Therapy Scientific Committee
  • Vaccine/IBT SC Scientific Research Agenda as of October 2007 - Dr. Coleen Cunningham, Chair PowerPoint
  • Update on VRC HIV Vaccine Development - Dr. Barney Graham, VRC PowerPoint
  • The STEP Study (Merck Protocol V520-023/HVTN 502) Update - Dr. Michelle Lally - HVTN PowerPoint
International Resource Committee
  • Interventions That Would Make Exclusive Formula Feeding Safe and Achievable - James McIntyre PowerPoint
  • Implications (Financial, Personnel and others) of implementation of ART earlier in the course of the disease in Developing Countries - Prof. Francis Mmiro, MD, FRCOG PowerPoint
  • "Should Poor Countries Now be Using HAART Instead of Dual Therapy ZDV+sdNVP to Reduce MTCT in Breast Feeders and Formula Feeders?" (United States) - Philip LaRussa, M.D. PowerPoint
  • "Should Poor Countries now be using HAART instead of Dual Therapy ZDV +sdNVP to Reduce MTCT in HIV infected women who choose to Breast feed?" (Uganda) - Prof. Francis Mmiro, MD, FRCOG PowerPoint
  • "Should poor countries now be using HAART instead of dual therapy [ZDV+ sd NVP] to reduce MTCT in breast feeders and formula feeders?" THE INDIA PERSPECTIVE - Gowri Sastry, M.D, M.P.H. PowerPoint
  • PMTCT in a Brazilian clinic- HAART is feasible in a middle income country - Breno Riegel Santos, M.D. PowerPoint
IMPAACT Community Advisory Board
  • The Big Picture: Overview and Structure of the International Maternal Pediatric Adolescent AIDS Clinical Trials Group PowerPoint
  • Capsule, Concept Sheet, and Protocol Development PowerPoint
  • Travel Expense Reports PowerPoint
  • IMPAACT Scientific Committees PowerPoint
  • An Introduction to Clinical Trials, Part II PowerPoint
  • Community Partners Overview: IMPAACT ICAB Orientation Presentation PowerPoint
  • Practical Issues - Mama Wandoa Mwambu PowerPoint
  • IMPAACT CAB Strategic Plan PowerPoint
Resource Committees